大島 吉輝 (おおしま よしてる)

略歴:

1977年東北大学大学院薬学研究科博士課程前期課程修了、その後、東北大学薬学部助手を経て、1996年4月から東北大学薬学部教授。2018年3月東北大学定年退職

 

 

 

現職:

東北大学大学院医学系研究科附属創生応用医学研究センター特任教授

 

 

最近の業績(和文):

 

1. 糸状菌二次代謝のエピジェネティック制御と天然物探索

 浅井禎吾、大島吉輝 

 化学と生物, 51 (1), 13-21 (2013)

 

2. 多様性拡大抽出物を利用した天然化合物ライブラリーの構築

 菊地晴久、大島吉輝

 MEDCHEM NEWS, 24 (2), 45-51 (2014)

 

3.微生物の可能性を開拓する ー多様な新規化合物合成のための新しいアプローチ

 浅井禎吾、大島吉輝

 現代化学, (546), 21-26 (2016)

 

4. エピジェネティック制御を利用する新規医薬資源の開拓

 浅井禎吾、大島吉輝

 生化学, 88, 643-648 (2016)

 

5. 非酵素的ポリケタイド二量化反応の発見と多様な擬天然物の半合成

 ー多様性指向型半合成による新たな天然物ケミカルスペースの開拓ー

 浅井禎吾、大島吉輝

 化学と生物, 55 (3), 152-154 (2017)

 

6. 多様性拡大抽出物が生み出す薬理活性指向型化合物ライブラリー

 菊地晴久、大島吉輝

 有機合成化学協会誌, 75 (4), 349-359 (2017)

 

 

最近の業績(英文):

 

1. Autophagic control of listeria through intracellular innate immune recognition in  

   drosophila

   T. Yano, S. Mita, H. Ohmori, Y.Oshima, Y. Fujimoto, R. Ueda, H. Takada, W. E.

   Goldman, K. Fukase, N. Silverman,T. Yoshimori and S. Kurata

   Nature Immunol., 9, 908-916 (2008)

 

2. Structures of the dimeric and monomeric chromanones, gonytolides A-C,

   isolated from the fungus Gonytrichum sp. and their promoting activities of innate 

   immune responses

   H. Kikuchi, M. Isobe, M. Sekiya, Y. Abe, T.Hoshikawa, K. Ueda, S. Kurata,

    Y. Katou and Y. Oshima

   Org.Lett., 13, 4624-4627(2011)

 

3. Tenuipyrone, a novel skeletal polyketide from the entomopathogenic fungus, 

   Isaria tenuipes, cultivated in the presence of epigenetic modifiers

   T. Asai, Y.-M. Chung, H. Sakurai, T. Ozeki, F.-R. Chang, K. Yamashita and Y.

   Oshima

   Org. Lett.,14, 513-515 (2012)

 

4. Aromatic polyketide production in Cordyceps indigotica, an entomopathogenic

   fungus, induced by exposure to a histone deacetylase inhibitor

   T. Asai, T. Yamamoto, K. Yamashita and Y. Oshima

   Org. Lett., 14, 2006-2009 (2012)

 

5. Structural diversity of new C13-polyketides produced by Chaetomium mollipilium

    cultivated in the presence of NAD+-dependent histone deacetylase inhibitor

   T.Asai, S. Morita, N. Shirata, T. Taniguchi, K. Monde, H. Sakurai, T. Ozeki and Y.

   Oshima

   Org.Lett., 14, 5456-5459 (2012)

 

6. Structures and biomimetic synthesis of polyketides of an endophytic

   Penicillium sp. of Cataranthus roseus

   T. Asai, D. Luo, K. Yamashita and Y. Oshima

   Org.Lett., 15,1020-1023 (2013)

 

7. Benzophenones of an endophytic fungus, Graphiopsis chlorocephalum, from  

    Paeonia lactiflora cultivated in the presence of an NAD+ dependent HDAC

    inhibitor

    T. Asai, S. Otsuki, H. Sakurai, T. Ozeki, K. Yamashita and Y. Oshima

    Org.Lett., 15,2058-2061 (2013)

 

8. Structurally diverse chaetophenol productions induced by chemically mediated

    epigenetic manipulation of fungal gene expression

    T. Asai, T. Yamamoto, N. Shirata, T. Taniguchi, K. Monde,I. Fujii, K. Gomi and 

    Y.  Oshima

    Org.Lett., 15,3346-3349 (2013)

 

9. Structures of spiroindicumides A and B, unprecedented carbon skeletal

    spirolactones from Chaetomium indicum and determination of

    the absolute configuration by VCD exciton approach

    T. Asai, T. Taniguchi, K. Monde and Y. Oshima

    Org.Lett., 15, 4320-4323 (2013)

 

10. Development of diversity-enhanced extracts of Curcuma zedoaria and their

     unprecedented sesquiterpene-like compounds

     H. Kikuchi, K. Sakurai and Y. Oshima

     Org. Lett., 16,1916-1919 (2014)

 

11. Use of a biosynthetic intermediate to explore the chemical diversity of peudo- 

      natural fungal polyketides

      T. Asai, K.Tsukada, S. Ise, N. Shirata, M. Hashimoto, I. Fujii, K. Gomi, K.

      Nakagawara, E. N. Kodama and Y. Oshima

      Nature Chem., 7, 737-743 (2015)

 

12. Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for

     development of drugs against malaria and toxoplasmosis

     V. Jain, M. Yogavel, Y. Oshima, H. Kikuchi, B.Touquet, M.-A. Hakimi and A.

     Sharma

     Structure, 23, 1-11 (2015)

 

13. The role of phylogenetically conserved cochaperone protein Droj2/DNAJA3

      in NF-κB signaling

      Y. Momiuchi, K. Kumada, T. Takagaki, T. Kuraishi, T. Aigaki, Y. Oshima and

      S. Kurata

      J. Biol. Chem., 290, 23816-23825 (2015)

 

14. Monoterpene indole alkaloid-like compounds based on diversity-enhnaced

     extracts of iridoid-containing plants and their immune checkpoint inhibitory

     activity

     H. Kikuchi, K. Ichinohe, S. Kida, S. Murase, O. Yamada and Y. Oshima

     Org. Lett., 18, 5948-5951 (2016)

 

15. Development of terpenoid alkaloid-like compound library based on a humulene

      skeleton

      H.Kikuchi, T. Nishimura, E. Kwon, J. Kawai and Y. Oshima

      Chem. Eur. J.,22, 15819-15825 (2016)

 

16. Halofuginone enhances chemo-sensitivity of cancer cells by suppressing NRF2

      accumulation

      K. Tsuchida, T. Tsujita, M.Hayashi, A. Ojima, N. Keleku-Lukwete, F. Katsuoka,

      A. Ohtsuki, H. Kikuchi, Y.Oshima, M. Suzuki and M. Yamamoto

     Free Radical Biol. Med., 103, 236-247 (2017)

 

17. Targeting prolyl-tRNA synthetase to accelerate drug discovery

      against malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis, and

      cocciodiosis

      V. Jain, M. Yogavel, H. Kikuchi, Y. Oshima, N.Hariguchi, M. Matsumoto, R.

      S. Jumani, B. Touquet, F. Tacchini-Cottier, C. D.Huston, M.-A. Hakimi and A.

      Sharma

      Structure, 25, 1495-1505 (2017)


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