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研究業績:宮田敏男

 

 

宮田 敏男 (みやた としお)

 

略歴:

1986年名古屋大学医学部卒業、その後、大阪大学微生物病研究所助手、名古屋大学医学部分院内科講師を経て、200711月末まで東海大学医学部腎・代謝内科学教授、総合医学研究所所長。

 

現職:

東北大学大学院医学系研究科 教授、研究科長補佐
東北大学 副理事(研究担当)、研究推進本部副本部長 

兼務:

ベルギー王室医学アカデミー 会員(生涯)
日本医療研究開発機構 科学技術顧問
ノースウェスタン大学 客員教授
東海大学 客員教授

受賞:

1993 日本内科学会奨励賞

1995 日本腎臓学会大島賞

2001 財団法人長寿科学振興財団奨励賞

2002 日本臨床分子医学会学術奨励賞

2002 東海大学松前重義賞

 

最近の業績:

TGF-β-induced intracellular PAI-1 is responsible for retaining   hematopoietic stem cells in the niche.

Yahata T, Ibrahim A, Muguruma Y, Eren M, Shaffer AM, Watanabe N, Kaneko S, Nakabayashi N, Dan T,   Hirayama N, Vaughan DE, Miyata T, Ando K.

Blood.Epub ahead of print

blood-2017-02-767384.full.pd.pdf
PDFファイル 2.4 MB

 PAI-1 is a critical regulator of FGF23 homeostasis.

Eren M, Place AT, Thomas PM, Flevaris P, Miyata T, Vaughan DE.

Science Advances.2017;3: e1603259

Science FGF23.pdf
PDFファイル 772.7 KB

Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.

Honjo T, Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, Dhahri D, Ichimura A, Dan T, Miyata T, Takeda K, Sakamoto K, Hattori K, Heissig B.

The FASEB Journal.2017 ;31:2625-2637

FASEB J-2017-Honjo-fj.201600871RR.pdf
PDFファイル 6.4 MB

 

A small molecule inhibitor of PAI-1 protects against Doxorubicin-induced cellular senescence: molecular basis.

Ghosh AK, Rai R, Park KE, Eren M, Miyata T, Wilsbacher LD, Vaughan DE.

Oncotarget.2016; 7:72443-72457

oncotarget.pdf
PDFファイル 1.5 MB

 

Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma.

Liu RM, Eldridge S, Watanabe N, Deshane J, Kuo HC, Jiang C, Wang Y, Liu G, Schwiebert L, Miyata T, Thannickal VJ.

Am J Physiol Lung Cell Mol Physiol.2016; 15: 328-336.

Am J Physiol Lung Cell Mol Physio 2016 1
PDFファイル 1.2 MB

 

Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model.

Jeong BY, Uddin MJ, Park JH, Lee JH, Lee HB, Miyata T, Ha H.

PLoS One.2016; 11: e0157012.

Plos one 2016 11 e0157012.pdf
PDFファイル 3.2 MB

 

A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects against high-fat diet-induced obesity and adipocyte injury in mice.

Piao L,Jung I, Huh JY, Miyata T, Ha H.

British J Pharmacology.2016; 173:2622-2632.

British J Pharmacology 2016 173 2622-263
PDFファイル 1.1 MB

 

Delayed intervention with pyridoxamine improves metabolic function and prevents adipose tissue inflammation and insulin resistance in high-fat diet-induced obese mice.

Maessen DE, Brouwers O, Gaens KH, Wouters K, Cleutjens JP, Janssen BJ, Miyata T, Stehouwer CD, Schalkwijk CG.

Diabetes.2016; 65: 956-966.

No268_Diabetes 2016 65 956-966.pdf
PDFファイル 2.1 MB


Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity.

Placencio VR, Ichimura A, Miyata T, DeClerck YA.

PLoS One.2015; 10: e0133786.

PLoS One 2015 10 e0133786.pdf
PDFファイル 3.5 MB

 

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.

Souma T, Nezu M, Nakano D, Yamazaki S, Hirano I, Sekine H, Dan T, Takeda K, Fong GH, Nishiyama A, Ito S, Miyata T, Yamamoto M, Suzuki N.

J Am Soc Nephrol. 2016; 27: 428-438.

J Am Soc Nephrol 2015.pdf
PDFファイル 2.5 MB


Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis.

Pelisch N, Dan T, Ichimura A, Sekiguchi H, Vaughan DE, van Ypersele de Strihou C, Miyata T.

PLoS One. 2015; 10: e0124510.

PLoS One 2015 10 e0124510.pdf
PDFファイル 6.8 MB

 

Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via beta 1 integrin endocytosis.

Kobayashi N, Ueno T, Ohashi K, Yamashita H, Takahashi Y, Sakamoto K, Manabe S, Hara S, Takashima Y, Dan T, Pastan I, Miyata T, Kurihara H, Matsusaka T, Reiser J, Nagata M.

Am J Physiol Renal Physiol.2015; 308:F614-26.

Am J Physiol Renal Physiol 2015 308 F614
PDFファイル 7.7 MB


Nitric oxide prevents alveolar senescence and emphysema in a mouse model.

Boe AE, Eren M, Morales-Nebreda L, Murphy SB, Budinger GR, Mutlu GM, Miyata T, Vaughan DE.

PLoS One. 2015; 10: e0116504.

PLoS One 2015 10 e0116504..pdf
PDFファイル 565.9 KB

 

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

Eren M, Boe A, Murphy SB, Place AT,  Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GS, Mutlu GM, Miyata T, Vaughan DE.

Proc Natl Acad Sci USA. 2014; 111: 7090-7095.

Proc Natl Acad Sci USA 2014 111 7090-70
PDFファイル 1.3 MB

 

Drug discovery in renal disease —towards a more efficient framework

Miyata T, Ando T, Hiragi H, Watanabe K, Yamamoto F, Vaughan DE, Kurokawa T, Oshima Y, van Ypersele de Strihou C, Takeuchi M.

Nat Rev Nephrol. 2014; 10: 290-296.

Nat Rev Nephrol 2014 10 290-296..pdf
PDFファイル 759.2 KB

 

Inhibition of Plasminogen Activator Inhibitor Type-1 Activity Enhances Rapid and Sustainable Hematopoietic Regeneration

Ibrahim A.A, Yahata T, Onizuka M, Dan T, van Ypersele de Strihou C, Miyata T, Ando K.

Stem Cells 2014; 32: 946-58.

Stem Cells 2014 32 946-58..pdf
PDFファイル 856.8 KB

 

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model
of diabetes

Brouwers O, Niessen PM, Miyata T, Østergaard JA, Flyvbjerg A, Peutz-Kootstra CJ, Sieber J, Mundel PH, Brownlee M, Janssen BJ, De Mey JG, Stehouwer CD, Schalkwijk CG.

Diabetologia 2014; 57: 224-235.

Diabetologia 2014 57 224-235..pdf
PDFファイル 620.5 KB

 

The PAI-1 antagonist TM5441 attenuates L-NAME-induced hypertension and vascular senescence

Boe A, Eren M, Murphy S, Kamide1 C, Ichimura A, Terry D, McAnally D, Smith LH, Miyata T, Vaughan DE.

Circulation 2013; 128: 2318-2324.

Circulation 2013 128 2318-2324..pdf
PDFファイル 1.1 MB

 

Kidney failure: aims for the next 10 years and barriers to success

Remuzzi G, Benigni A, Finkelstein FO, Grunfeld JP, Joly D, Katz I, Liu ZH, Miyata T, Perico N, Rodriguez-Iturbe B, Antiga L, Schaefer F, Schieppati A, Schrier RW, Tonelli M.

Lancet 2013; 382: 353-362.

Lancet 2013 382 353-362..pdf
PDFファイル 5.9 MB

 

Diabetic nephropathy: Are there new and potentially promising therapies targeting oxygen biology?

Miyata T, Suzuki N, van Ypersele de Strihou C.

Kidney Int 2013; 84: 693-702.

Kidney Int 2013 84 693-702..pdf
PDFファイル 1.2 MB

 

A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration

Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou C, Miyata T.

Arterioscler Thromb Vasc Biol. 2013; 33: 935-942.

Arterioscler Thromb Vasc Biol 2013 935-
PDFファイル 2.2 MB

 

Metabolic stress response implicated in diabetic retinopathy:the role of calpain, and the therapeutic impact of calpain inhibitor.

Shanab AY, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K, Yasuda M, Watanabe R, Takano J, Takaomi S, Minegishi N, Miyata T, Abe T, Yamamoto M.

Neurobiology of Disease 2012; 48: 556-567. 

Neurobiology of Disease 2012 48 556-567.
PDFファイル 2.1 MB

 

The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.

Zhou LL, Cao W, Xie C, Tian J, Zhou Z, Zhou Q, Zhu P, Li A, Liu Y, Miyata T, Hou FF, Nie J.

Kidney Int 2012; 82: 759-770. 

Kidney Int 2012 82 759-770.pdf
PDFファイル 527.3 KB

 

Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.

Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Dan T, Miyata T, Okumura K, Tomiki Y, Sakamoto K, Nakauchi H, Heissig B, Hattori K.

Blood 2012; 119: 6382-6393.

Blood 2012; 119 6382-6393..pdf
PDFファイル 940.1 KB

 

Protection against methylglyoxal-derived AGEs by regulation of glyoxalse-1 prevents retinal neuroglial and vasodegenerative pathology.

Berner AK, Brouwers O, Pringle R, Klaassen I, Colhoun L, McVicar C, Brockbank S, Curry JW, Miyata T, Brownlee M, Schlingemann RO, Schalkwijk C, Stitt AW. Diabetologia 2012; 55: 845-854.

Diabetologia 2012 55 845-854..pdf
PDFファイル 579.5 KB

 

Skin advanced glycation end product accumulation is negatively associated with calcaneal osteo-sono assessment index among non-diabetic adult Japanese men.
Momma H, Niu K, Kobayashi Y, Guan L, Sato M, Guo H, Chujo M, Otomo A, Yufei C, Tadaura H, Saito T, Mori T, Miyata T, Nagatomi R.

Osteoporos Int 2012; 23: 1673-1681.

Osteoporos Int 2012 23 1673-1681..pdf
PDFファイル 396.7 KB

 

Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis.

Huang WT, Vayalil PK, Miyata T, Hagood J, Liu RM.

Am J Respir Cell Mol Biol. 2012; 46: 87-95.

Am J Respir Cell Mol Biol. 2012 46 87-95
PDFファイル 1.7 MB

 

Glyoxalase I retards renal senescence.

Ikeda Y, Inagi R, Miyata T, Nagai R, Arai M, Miyashita M, Itokawa M, Fujita T, Nangaku M.

Am J Pathol 2011; 179: 2810-2821.

Am J Pathol 2011 179 2810-2821..pdf
PDFファイル 2.7 MB

  

   New era for drug discovery and development in renal disease.

   Miyata T, Kikuchi K, Kiyomoyo H,van Ypersele de Strihou C.

   Nat Rev Nephrol 2011; 7: 469-477.

Nat Rev Nephrol 2011 7 469-477..pdf
PDFファイル 761.1 KB

 

In Oxidative Stress in Applied Basic Research and Clinical Practice: Studies on Renal Disorders (Springer),

edited by Toshio MIyata, Kai-Uwe Eckardt, Masaomi Nangaku.

Studies on Renal Disorders.pdf
PDFファイル 75.6 KB

 

Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets.

Miyata T, Takizawa S,van Ypersele de Strihou C.

Am J Physiol Cell Physiol 2011; 300: 226-231.

Am J Physiol Cell Physiol 2011 300 226-2
PDFファイル 605.0 KB

 

Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients.

Kakuta T, Tanaka R, Hyodo T, Suzuki H, Kanai G, Nagaoka M, Takahashi H, Hirawa N, Oogushi Y, Miyata T, Kobayashi H, Fukagawa M, Saito A.

Am J Kidney Dis 2011; 57: 422-431.

Am J Kidney Dis 2011 57 422-431..pdf
PDFファイル 1.4 MB

 

Overexpression of Glyoxalase-I Reduces Hyperglycemia–induced Levels of Advanced Glycation Endproducts and Oxidative Stress in Diabetic Rats.

Brouwers O, Niessen PM, Ferreira I, Miyata T, Scheffer PG, Teerlink T, Schrauwen P, Brownlee M, Stehouwer CD, Schalkwijk CG. 

J Biol Chem2011; 286: 1374-1380.

J Biol Chem. 2011 286 1374-1380..pdf
PDFファイル 1.1 MB

 

Enhanced carbonyl stress in a subpopulation of schizophrenia.

Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A,Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M.  

Arch Gen Psychiatry 2010; 67: 589-597.

Arch Gen Psychiatry 2010 67 589-597.pdf
PDFファイル 180.3 KB

 

Diabetic nephropathy: a disorder of oxygen metabolism?

Miyata T, van Ypersele de Strihou C.

Nat Rev Nephrol. 2010; 6: 83-95.

Nat Rev Nephrol. 2010 6 83-95.pdf
PDFファイル 707.1 KB

詳細な研究業績については、下記URLをご参照下さい。

http://www.researcherid.com:80/rid/A-4872-2010


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