大島 吉輝 (おおしま よしてる)
略歴:
1977年東北大学大学院薬学研究科博士課程前期課程修了、その後、東北大学薬学部助手を経て、1996年4月から東北大学薬学部教授。2018年3月東北大学定年退職
現職:
東北大学大学院医学系研究科附属創生応用医学研究センター特任教授
最近の業績(和文):
1. 糸状菌二次代謝のエピジェネティック制御と天然物探索
浅井禎吾、大島吉輝
化学と生物, 51 (1), 13-21 (2013)
2. 多様性拡大抽出物を利用した天然化合物ライブラリーの構築
菊地晴久、大島吉輝
MEDCHEM NEWS, 24 (2), 45-51 (2014)
3.微生物の可能性を開拓する ー多様な新規化合物合成のための新しいアプローチ
浅井禎吾、大島吉輝
現代化学, (546), 21-26 (2016)
4. エピジェネティック制御を利用する新規医薬資源の開拓
浅井禎吾、大島吉輝
生化学, 88, 643-648 (2016)
5. 非酵素的ポリケタイド二量化反応の発見と多様な擬天然物の半合成
ー多様性指向型半合成による新たな天然物ケミカルスペースの開拓ー
浅井禎吾、大島吉輝
化学と生物, 55 (3), 152-154 (2017)
6. 多様性拡大抽出物が生み出す薬理活性指向型化合物ライブラリー
菊地晴久、大島吉輝
有機合成化学協会誌, 75 (4), 349-359 (2017)
最近の業績(英文):
1. Autophagic control of listeria through intracellular innate immune recognition in
drosophila
T. Yano, S. Mita, H. Ohmori, Y.Oshima, Y. Fujimoto, R. Ueda, H. Takada, W. E.
Goldman, K. Fukase, N. Silverman,T. Yoshimori and S. Kurata
Nature Immunol., 9, 908-916 (2008)
2. Structures of the dimeric and monomeric chromanones, gonytolides A-C,
isolated from the fungus Gonytrichum sp. and their promoting activities of innate
immune responses
H. Kikuchi, M. Isobe, M. Sekiya, Y. Abe, T.Hoshikawa, K. Ueda, S. Kurata,
Y. Katou and Y. Oshima
Org.Lett., 13, 4624-4627(2011)
3. Tenuipyrone, a novel skeletal polyketide from the entomopathogenic fungus,
Isaria tenuipes, cultivated in the presence of epigenetic modifiers
T. Asai, Y.-M. Chung, H. Sakurai, T. Ozeki, F.-R. Chang, K. Yamashita and Y.
Oshima
Org. Lett.,14, 513-515 (2012)
4. Aromatic polyketide production in Cordyceps indigotica, an entomopathogenic
fungus, induced by exposure to a histone deacetylase inhibitor
T. Asai, T. Yamamoto, K. Yamashita and Y. Oshima
Org. Lett., 14, 2006-2009 (2012)
5. Structural diversity of new C13-polyketides produced by Chaetomium mollipilium
cultivated in the presence of NAD+-dependent histone deacetylase inhibitor
T.Asai, S. Morita, N. Shirata, T. Taniguchi, K. Monde, H. Sakurai, T. Ozeki and Y.
Oshima
Org.Lett., 14, 5456-5459 (2012)
6. Structures and biomimetic synthesis of polyketides of an endophytic
Penicillium sp. of Cataranthus roseus
T. Asai, D. Luo, K. Yamashita and Y. Oshima
Org.Lett., 15,1020-1023 (2013)
7. Benzophenones of an endophytic fungus, Graphiopsis chlorocephalum, from
Paeonia lactiflora cultivated in the presence of an NAD+ dependent HDAC
inhibitor
T. Asai, S. Otsuki, H. Sakurai, T. Ozeki, K. Yamashita and Y. Oshima
Org.Lett., 15,2058-2061 (2013)
8. Structurally diverse chaetophenol productions induced by chemically mediated
epigenetic manipulation of fungal gene expression
T. Asai, T. Yamamoto, N. Shirata, T. Taniguchi, K. Monde,I. Fujii, K. Gomi and
Y. Oshima
Org.Lett., 15,3346-3349 (2013)
9. Structures of spiroindicumides A and B, unprecedented carbon skeletal
spirolactones from Chaetomium indicum and determination of
the absolute configuration by VCD exciton approach
T. Asai, T. Taniguchi, K. Monde and Y. Oshima
Org.Lett., 15, 4320-4323 (2013)
10. Development of diversity-enhanced extracts of Curcuma zedoaria and their
unprecedented sesquiterpene-like compounds
H. Kikuchi, K. Sakurai and Y. Oshima
Org. Lett., 16,1916-1919 (2014)
11. Use of a biosynthetic intermediate to explore the chemical diversity of peudo-
natural fungal polyketides
T. Asai, K.Tsukada, S. Ise, N. Shirata, M. Hashimoto, I. Fujii, K. Gomi, K.
Nakagawara, E. N. Kodama and Y. Oshima
Nature Chem., 7, 737-743 (2015)
12. Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for
development of drugs against malaria and toxoplasmosis
V. Jain, M. Yogavel, Y. Oshima, H. Kikuchi, B.Touquet, M.-A. Hakimi and A.
Sharma
Structure, 23, 1-11 (2015)
13. The role of phylogenetically conserved cochaperone protein Droj2/DNAJA3
in NF-κB signaling
Y. Momiuchi, K. Kumada, T. Takagaki, T. Kuraishi, T. Aigaki, Y. Oshima and
S. Kurata
J. Biol. Chem., 290, 23816-23825 (2015)
14. Monoterpene indole alkaloid-like compounds based on diversity-enhnaced
extracts of iridoid-containing plants and their immune checkpoint inhibitory
activity
H. Kikuchi, K. Ichinohe, S. Kida, S. Murase, O. Yamada and Y. Oshima
Org. Lett., 18, 5948-5951 (2016)
15. Development of terpenoid alkaloid-like compound library based on a humulene
skeleton
H.Kikuchi, T. Nishimura, E. Kwon, J. Kawai and Y. Oshima
Chem. Eur. J.,22, 15819-15825 (2016)
16. Halofuginone enhances chemo-sensitivity of cancer cells by suppressing NRF2
accumulation
K. Tsuchida, T. Tsujita, M.Hayashi, A. Ojima, N. Keleku-Lukwete, F. Katsuoka,
A. Ohtsuki, H. Kikuchi, Y.Oshima, M. Suzuki and M. Yamamoto
Free Radical Biol. Med., 103, 236-247 (2017)
17. Targeting prolyl-tRNA synthetase to accelerate drug discovery
against malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis, and
cocciodiosis
V. Jain, M. Yogavel, H. Kikuchi, Y. Oshima, N.Hariguchi, M. Matsumoto, R.
S. Jumani, B. Touquet, F. Tacchini-Cottier, C. D.Huston, M.-A. Hakimi and A.
Sharma
Structure, 25, 1495-1505 (2017)